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Alpha-lipoic acid for nerve pain

Alpha-lipoic acid for nerve pain

Supplier Information. This is a Alph-alipoic change that includes lain, burning, pain, A,pha-lipoic Alpha-lipoic acid for nerve pain in parts of Alpha-lipoic acid for nerve pain skin. To provide you with the most Blackberry ice cream recipe and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. An oral dose of mg once daily appears to provide the optimum risk-to-benefit ratio. Apha-lipoic acid can combine with these drugs to lower blood sugar levels, raising the risk of hypoglycemia or low blood sugar.


7 Incredible Vitamins To Repair Nerve Damage We fir products we think fof useful for our Alpha-lipoic acid for nerve pain. Dental plaque you buy through links on Alpha-lipic page, we may earn a small commission. Healthline only shows you brands and products that we stand behind. Alpha-lipoic acid may provide health benefits, including supporting weight loss and lowering blood sugar levels. You can get it through food and supplements with minimal side effects.

Alpha-lipoic acid for nerve pain -

Using this invasive technique, intra-arterial infusion of lipoic acid was found to improve endothelium-dependent vasodilation in 39 subjects with type 2 diabetes but not in 11 healthy controls A more recent randomized , double-blind , placebo -controlled study in 30 patients with type 2 diabetes found that intravenous infusion of mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate Another noninvasive technique using ultrasound to measure flow-mediated vasodilation was used in two additional studies conducted by Xiang et al.

The results of these randomized, placebo-controlled studies showed that intravenous lipoic acid could improve endothelial function in patients with impaired fasting glucose 64 or impaired glucose tolerance Peripheral neuropathy is also a leading cause of lower limb amputation in diabetic patients Several mechanisms have been proposed to explain chronic hyperglycemia -induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress reviewed in The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation However, evidence of the efficacy of enhanced control of glycemia in preventing neuropathy is stronger in patients with type 1 diabetes than in those with type 2 diabetes Moreover, this glucose control intervention increased the risk of hypoglycemic episodes The efficacy of lipoic acid, administered either intravenously or orally, in the management of neuropathic symptoms has been examined in patients with diabetes.

Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took mg of lipoic acid three times a day for three weeks compared to those who took a placebo Evidence of improvements in sensory and motor deficits — assessed by physicians — could be observed after three weeks of intravenous lipoic acid therapy, yet not at the end of six months of oral lipoic acid therapy.

Yet, measures of specific neuropathic impairments secondary outcomes improved with lipoic acid supplementation A post-hoc analysis suggested that oral lipoic acid supplementation may reduce neuropathic symptoms particularly in subjects with a high burden of cardiovascular disease , diabetes, and neuropathy yet with normal body mass index BMI and blood pressure CAN is characterized by damage to the nerve fibers that innervate the heart and blood vessels, leading to reduced heart rate variability variability in the time interval between heartbeats and increased risk of mortality Summary: Overall, the available research suggests that treatment with intravenous or oral lipoic acid may help reduce symptoms of diabetic peripheral neuropathy.

The use of lipoic acid is currently approved for the treatment of diabetic neuropathy in Germany 4. It is important to note that many of the studies that examined the efficacy of lipoic acid in the treatment of diabetic neuropathy have been primarily conducted by one German research group and funded by the manufacturer of lipoic acid in Germany Chronic hyperglycemia can damage blood vessels in the retina and cause a potentially sight-threatening condition called diabetic retinopathy One placebo-controlled study examined the effect of lipoic acid on the visual capability of 80 participants of whom 12 had type 1 diabetes, 48 had type 2 diabetes, and 20 were diabetes-free.

The result showed that daily oral administration of mg of lipoic acid for three months prevented the deterioration of contrast sensitivity in patients with diabetes and improved it in healthy patients compared to placebo Multiple sclerosis is an autoimmune disease of unknown etiology that is characterized by the progressive destruction of myelin and nerve fibers in the central nervous system , causing neurological symptoms in affected individuals There are four main types of multiple sclerosis defined according to the disease course: i clinically isolated syndrome, ii relapsing-remitting multiple sclerosis, iii secondary progressive multiple sclerosis, and iv primary progressive multiple sclerosis for more information, visit the National Multiple Sclerosis Society website Lipoic acid was found to effectively slow disease progression when administered either orally 87 , intraperitoneally 88 , or subcutaneously 89 to mice with experimental autoimmune encephalomyelitis EAE , a model of multiple sclerosis.

Only a few studies have examined lipoic acid supplementation in humans. In this study, higher serum concentrations of lipoic acid were associated with the lowest serum concentrations of MMP-9 — a marker of inflammation Another study suggested that an oral dose of 1, mg of lipoic acid in subjects with multiple sclerosis could help achieve serum lipoic acid concentrations similar to those found to be therapeutic in mice Supplemental lipoic acid also decreased the serum concentrations of some IFN-γ, ICAM-1, TGF-γ, IL-4 , but not all markers TNF-γ, IL-6, MMP-9 , cytokines and other inflammation In addition, lipoic acid supplementation did not reduce the severity of multiple sclerosis symptoms, as assessed by the Expanded Disability Status Scale EDSS scoring system 98, It is not known whether oral lipoic acid supplementation can slow cognitive decline related to aging or pathological conditions in humans.

However, the significance of these findings is difficult to assess without a control group for comparison. Interestingly, patients who took fish oil concentrate together with lipoic acid showed no worsening of global cognitive function as assessed by the Mini-Mental State Examination [MMSE] score system over 12 months as opposed to those who took either the fish oil concentrate alone or a placebo A meta-analysis of randomized , placebo -controlled trials found that lipoic acid supplementation in those with high body mass index BMI resulted in significant, yet modest, reductions in weight 9 studies and BMI 11 studies in the absence of caloric restriction except in one study There was no reduction in waist circumference with supplemental lipoic acid 5 studies Substantial weight and BMI reductions with lipoic acid supplementation in overweight or obese subjects were also reported in a prior meta-analysis R -lipoic acid is synthesized endogenously by humans see Metabolism and Bioavailability.

R -lipoic acid occurs naturally in food covalently bound to lysine in proteins lipoyllysine; see Figure 1. Although lipoic acid is found in a wide variety of foods from plant and animal sources, quantitative information on the lipoic acid or lipoyllysine content of food is limited; published databases are lacking.

Somewhat lower amounts of lipoyllysine ~0. Unlike lipoic acid in foods, lipoic acid in supplements is not bound to protein. Moreover, the amounts of lipoic acid available in dietary supplements mg are likely as much as 1, times greater than the amounts that could be obtained from the diet.

In Germany, lipoic acid is approved for the treatment of diabetic neuropathies and is available by prescription Lipoic acid is available as a dietary supplement without a prescription in the US. Most lipoic acid supplements contain a racemic mixture of R -lipoic acid and S -lipoic acid sometimes noted d,l -lipoic acid.

Supplements that claim to contain only R -lipoic acid are usually more expensive, and information regarding their purity is not publicly available Since taking lipoic acid with a meal decreases its bioavailability , it is generally recommended that lipoic acid be taken 30 min prior to a meal see also Metabolism and Bioavailability 8.

R -lipoic acid is the isomer that is synthesized by plants and animals and functions as a cofactor for mitochondrial enzymes in its protein -bound form see Biological Activities. Direct comparisons of the bioavailability of the oral racemic mixture and R -lipoic acid supplements have not been published.

Both isomers were nonetheless rapidly metabolized and eliminated 6 , 8 , In rats, R -lipoic acid was more effective than S -lipoic acid in enhancing insulin -stimulated glucose transport and metabolism in skeletal muscle , and R -lipoic acid was more effective than R,S -lipoic acid and S -lipoic acid in preventing cataracts However, all of the published human studies have used R,S -lipoic acid racemic mixture.

It has been suggested that the presence of S -lipoic acid in the racemic mixture may limit the polymerization of R -lipoic acid and enhance its bioavailability At present, it remains unclear which supplemental form is best to use in clinical trials.

In general, high-dose lipoic acid administration has been found to have few serious side effects. Two mild anaphylactoid reactions and one severe anaphylactic reaction, including laryngospasm, were reported after intravenous lipoic acid administration The most frequently reported side effects of oral lipoic acid supplementation are allergic reactions affecting the skin, including rashes, hives, and itching.

Abdominal pain, nausea, vomiting, diarrhea, and vertigo have also been reported, and one trial found that the incidence of nausea, vomiting, and vertigo was dose-dependent A retrospective observational study reported that daily oral supplementation with mg of lipoic acid racemic mixture during pregnancy and without interruption from a period spanning between week 10 and week 30 of gestation and until the end of week 37 was not associated with any adverse effect in mothers and their newborns In absence of further evidence, lipoic acid supplementation during pregnancy should only be considered under strict medical supervision.

The safety of lipoic acid supplements in lactating women has not been established and should thus be discouraged A case of intoxication was reported in a month old child The child was admitted to hospital with seizure , acidosis, and unconsciousness. Symptomatic management and rapid elimination of lipoic acid led to a full recovery without sequelae within five days.

The non-accidental ingestion of a very high dose of lipoic acid led to multi-organ failure and subsequent death of an adolescent girl In theory, because lipoic acid supplementation may improve insulin -mediated glucose utilization see Diabetes mellitus , there is a potential risk of hypoglycemia in diabetic patients using insulin or oral anti-diabetic agents Consequently, blood glucose concentrations should be monitored closely when lipoic acid supplementation is added to diabetes treatment regimens.

The chemical structure of biotin is similar to that of lipoic acid, and there is some evidence that high concentrations of lipoic acid can compete with biotin for transport across cell membranes , Originally written in by: Jane Higdon, Ph.

Linus Pauling Institute Oregon State University. Updated in July by: Jane Higdon, Ph. Updated in April by: Jane Higdon, Ph.

Updated in January by: Victoria J. Drake, Ph. Updated in October by: Barbara Delage, Ph. Reviewed in January by: Tory M. Hagen, Ph. Principal Investigator, Linus Pauling Institute Professor, Dept. of Biochemistry and Biophysics Helen P.

Rumbel Professor for Healthy Aging Research Oregon State University. Reed LJ. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes.

J Biol Chem. Carreau JP. Biosynthesis of lipoic acid via unsaturated fatty acids. Methods Enzymol. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM.

Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. Kramer K, Packer L. R-alpha-lipoic acid. In: Kramer K, Hoppe P, Packer L, eds. Nutraceuticals in Health and Disease Prevention. New York: Marcel Dekker, Inc. Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W.

Lipoic acid biosynthesis defects. J Inherit Metab Dis. Hermann R, Niebch G, Borbe H, et al. Enantioselective pharmacokinetics and bioavailability of different racemic alpha-lipoic acid formulations in healthy volunteers.

Eur J Pharm Sci. Teichert J, Hermann R, Ruus P, Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J Clin Pharmacol. Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U.

Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur J Clin Pharmacol. Brufani M, Figliola R. R -alpha-lipoic acid oral liquid formulation: pharmacokinetic parameters and therapeutic efficacy.

Acta Biomed. Maglione E, Marrese C, Migliaro E, et al. Increasing bioavailability of R -alpha-lipoic acid to boost antioxidant activity in the treatment of neuropathic pain. Breithaupt-Grogler K, Niebch G, Schneider E, et al.

Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Evans JL, Heymann CJ, Goldfine ID, Gavin LA.

Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.

Endocr Pract. Keith DJ, Butler JA, Bemer B, et al. Age and gender dependent bioavailability of R- and R,S-alpha-lipoic acid: a pilot study. Pharmacol Res. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VA, Dieckmann CL, Kastaniotis AJ. Mitochondrial fatty acid synthesis and respiration. Biochim Biophys Acta.

Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JM. Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells.

Kozlov AV, Gille L, Staniek K, Nohl H. Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone.

Arch Biochem Biophys. May JM, Qu ZC, Mendiratta S. Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. Upston JM, Terentis AC, Stocker R. Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement.

Faseb J. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Doraiswamy PM, Finefrock AE. Metals in our minds: therapeutic implications for neurodegenerative disorders. Lancet Neurol. Ou P, Tritschler HJ, Wolff SP. Thioctic lipoic acid: a therapeutic metal-chelating antioxidant?

Biochem Pharmacol. Suh JH, Zhu BZ, deSzoeke E, Frei B, Hagen TM. Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.

Redox Rep. Suh JH, Moreau R, Heath SH, Hagen TM. Dietary supplementation with R -alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Yamamoto H, Watanabe T, Mizuno H, et al. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon LEC rats.

Free Radic Res. Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.

Altern Med Rev. Rooney JP. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury.

Hagen TM, Vinarsky V, Wehr CM, Ames BN. R -alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal. Busse E, Zimmer G, Schopohl B, Kornhuber B. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.

Monette JS, Gomez LA, Moreau RF, et al. R -alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Suh JH, Shenvi SV, Dixon BM, et al.

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A.

Suh JH, Wang H, Liu RM, Liu J, Hagen TM. R -alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.

Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z. Environ Toxicol Pharmacol. Fratantonio D, Speciale A, Molonia MS, et al. Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-alpha induced endothelium dysfunction.

Sena CM, Cipriano MA, Botelho MF, Seica RM. Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation. Int J Mol Sci. Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, et al.

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Fayez AM, Zakaria S, Moustafa D.

Biomed Pharmacother. Lin YC, Lai YS, Chou TC. The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase Evid Based Complement Alternat Med. Segal AW. The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals.

Int J Biochem Cell Biol. Dong Y, Wang H, Chen Z. Int J Endocrinol. Byun E, Lim JW, Kim JM, Kim H. alpha-Lipoic acid inhibits Helicobacter pylori-induced oncogene expression and hyperproliferation by suppressing the activation of NADPH oxidase in gastric epithelial cells.

Mediators Inflamm. Konrad D. Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation? Diesel B, Kulhanek-Heinze S, Holtje M, et al. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis.

Estrada DE, Ewart HS, Tsakiridis T, et al. Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S. Evidence that alpha-lipoic acid inhibits NF-kappaB activation independent of its antioxidant function.

Inflamm Res. Smith AR, Hagen TM. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by R -alpha-lipoic acid. Biochem Soc Trans. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.

Moura FA, de Andrade KQ, dos Santos JC, Goulart MO. Lipoic acid: its antioxidant and anti-inflammatory role and clinical applications. Curr Top Med Chem.

Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr. Rochette L, Ghibu S, Richard C, Zeller M, Cottin Y, Vergely C.

Direct and indirect antioxidant properties of alpha-lipoic acid and therapeutic potential. Mol Nutr Food Res. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.

Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Mayr JA, Zimmermann FA, Fauth C, et al.

Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. Am J Hum Genet. Tort F, Ferrer-Cortes X, Thio M, et al. Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes.

Hum Mol Genet. Ziegler D. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat Endocrinol. Nathan DM, Davidson MB, DeFronzo RA, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care.

Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Jacob S, Rett K, Henriksen EJ, Haring HU.

Thioctic acid--effects on insulin sensitivity and glucose-metabolism. de Oliveira AM, Rondo PH, Luzia LA, D'Abronzo FH, Illison VK. The effects of lipoic acid and alpha-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.

Diabetes Res Clin Pract. Akbari M, Ostadmohammadi V, Lankarani KB, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials.

Roberts AC, Porter KE. Cellular and molecular mechanisms of endothelial dysfunction in diabetes. Diab Vasc Dis Res. Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.

Heinisch BB, Francesconi M, Mittermayer F, et al. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest. Xiang G, Pu J, Yue L, Hou J, Sun H.

alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L.

The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol Oxf. Sola S, Mir MQ, Cheema FA, et al. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction ISLAND study.

National Institute of Diabetes and Digestive and Kidney Diseases. Diabetic Neuropathy. Malik RA, Tesfaye S, Ziegler D.

Medical strategies to reduce amputation in patients with type 2 diabetes. Diabet Med. Obrosova IG. Diabetes and the peripheral nerve. Dy SM, Bennett WL, Sharma R, et al. Alpha lipoic acid ALA is an antioxidant.

It is quickly absorbed from the gastrointestinal tract. It dissolves in both water and fat in the body. ALA is frequently used to treat diabetic neuropathy.

This is a sensory change that includes stinging, burning, pain, and numbness in parts of the skin. ALA hasn't been scientifically proven to be helpful in all cases of neuropathy. However, some studies have indicated its helpfulness in mild to moderate cases. It is used by many people with neuropathy.

Research continues to be in progress to evaluate ALA's effectiveness. Several small studies have also shown that ALA can help to increase insulin sensitivity.

It may lower blood sugar levels in people with diabetes. More research is needed to confirm this. ALA is a strong antioxidant. This function may protect nerve tissue from damage. Conditions, such as diabetes, may be helped by antioxidants such as ALA.

Alpha-lipoic acid ALA fkr a naturally-occurring fatty acid. Your body makes Alpha-lipoic acid for nerve pain own ;ain, but Alpha-lipoic acid for nerve pain is axid available in certain Joint health support system and as a supplement. ALA supplements may provide health benefits, such as aiding in weight loss and managing blood sugar, but more research needs to be done to support its use. This article reviews the potential uses of ALA and also covers side effects and possible interactions. Supplement use should be individualized and vetted by a healthcare provider. Alpha-lipoic acid for nerve pain

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