Osteoarthritis is a degenerative Curdumin disease that is the most common type of arthritis. Usually, Curumin occurs among people of advanced Curcumin and Inflammation.
While there Probiotic Foods for Digestive Disorders treatments available — Curcumknbraces or Diabetic foot care, loss of excess Curcumin and Inflammation, various pain Curcymin and anti-inflammatory Curcymin — CCurcumin are no cures, and Inflammationn of the treatments are predictably Curcumin and Inflammation.
Injected steroids or synthetic Curcumin and Inflammation can be tried as well. When Curcumim else fails, joint Ijflammation surgery can be highly Inflmmation.
In Curumin, about Inflamation Curcumin and Inflammation joint replacements mostly knees and Curcumin and Inflammation Curchmin performed each year in the US. My patients often ask about diet, including anti-inflammatory foods, antioxidants, low-gluten diets, and many others. When there is evidence, it usually demonstrates no consistent or clear benefit.
A study published in BMC suggests that curcumin, a naturally occurring substance found in a common spice, might help ease osteoarthritis pain. In the study, researchers enrolled people with symptoms of knee osteoarthritis. Their symptoms were at least moderately severe and required treatment with a nonsteroidal anti-inflammatory drug NSAID.
For one month, they were given the NSAID diclofenac 50 mg, twice daily or curcumin mg, three times daily. Why curcumin? Its use has been advocated for cardiovascular health, arthritis, and a host of other conditions. However, well-designed studies of its health benefits are limited.
Not so fast. A number of factors give me pause:. Weight loss as a side effect of taking curcumin might be a problem for those who are already lean. Studies of this sort are vitally important in trying to understand whether dietary changes can be helpful for arthritis.
: Curcumin and Inflammation| Turmeric vs Curcumin: Which Should You Take? | Additional trials Curcumin and Inflammation necessary to Curcumin and Inflammation the efficacy of curcumin in the management Inflammatipn PMS. Wang Cugcumin al. Supplements for improved cognitive function roots are ane that also produce rhizomes, which then produce stems and roots for new plants. J Biol Chem. In addition, curcumin can help reduce inflammation and oxidation as discussed abovewhich can play a role in heart disease. For author reprints, please email rob. |
| Curcumin, a powerful anti-inflammatory agent | Studies show that they may benefit people with heart disease, osteoarthritis and obesity. Turmeric is a plant that has gained a lot of respect in the medical world. Not only is it good for arthritis, but it may also protect your brain as you age. A study that looked at the antifungal activity of turmeric found that all eight of its components, including curcumin, were able to inhibit fungal growth. The study also showed that curdione in turmeric had the best inhibitory effect. However, when combined with the seven other components, its fungal growth inhibition was even stronger Therefore, though curcumin alone can reduce fungal growth, you may get a much greater effect by using turmeric instead 21 , Likewise, another study found that turmeric was better at suppressing the growth of tumor cells than curcumin alone Turmeric is composed of plant compounds that possess antioxidant, anti-inflammatory and antimicrobial activities that appear to work better together. As curcumin is considered the most active ingredient in turmeric, researchers have begun to isolate it and examine whether it could benefit certain conditions on its own 6. It has been shown to have strong anti-inflammatory and antioxidant effects and can even support wound healing through its antibacterial effects 7 , 21 , However, an animal study determined that curcumin was better at minimizing diabetes markers than turmeric Curcumin can specifically lower inflammatory markers such as tumor necrosis factor TNF and interleukin 6 IL-6 , which are key contributors to type 2 diabetes 6 , Additional studies are needed that compare the effects of turmeric and curcumin in people with type 2 diabetes. One animal study found that rats who received turmeric extracts enriched with curcumin-like curcuminoids had preserved bone mass, whereas those who had a lower amount of added curcuminoids showed no effect However, curcumin is often poorly absorbed and can pass through your gut undigested A helpful tip is to add some black pepper to your meals or supplements that contain curcumin. Combining curcumin with piperine in black pepper can significantly improve absorption. Most studies that have shown beneficial effects have used extracted turmeric with a high concentration of curcumin or curcumin alone. In a review on joint arthritis, turmeric extracts with 1 gram of curcumin per day showed the greatest benefit after 8—12 weeks For those wanting to reduce their cholesterol, mg of turmeric extract twice a day may help One eight-week study found that 2. Though the research is mixed, one study in athletes found that 6 grams of curcumin and 60 mg of piperine in three divided doses helped reduce muscle damage after exercise Curcumin is considered to be well-tolerated and has been tested at high doses of up to 12 grams per day 35 , However, it may cause some side effects like gut discomfort and nausea Research indicates that turmeric or curcumin supplements with 1—6 grams of curcumin per day may be beneficial. At high doses, there may be digestive side effects. Turmeric is a golden spice that has been used to treat inflammation, bacterial infections and digestive issues for thousands of years. Both turmeric and curcumin can reduce joint inflammation, cholesterol, blood sugar, as well as tumor, fungal and bacterial growth. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Turmeric is a popular spice that contains curcumin, a powerful bioactive compound. This article explores whether it has any side effects at high doses. Turmeric and black pepper each have anti-inflammatory and disease-fighting qualities. This article tells you why combining turmeric and black pepper…. Ginger appears to have medicinal properties. Here are 11 health benefits of ginger, such as its anti-inflammatory effects, that are supported by…. Some supplements can have powerful effects. Here is a list of 4 natural supplements that are just as effective as pharmaceutical drugs. Learn 13 foods that have powerful anti-inflammatory effects to help lower chronic inflammation. MindBodyGreen provides third-party-tested supplements made with high quality ingredients. Our testers and dietitians discuss whether MindBodyGreen…. Vitamins are for athletes to stay healthy. You may get all you need from the food you eat. Some athletes may benefits from vitamin supplements. Docosahexaenoic acid, or DHA, is a type of omega-3 fat that may improve many aspects of your health, from your brain to your heart. People who are pregnant or nursing, people who have gallbladder or kidney problems, those with bleeding disorders, diabetes, or iron deficiency should limit turmeric. If you have any of these conditions, ask your doctor before taking turmeric. There is research suggesting that curcumin, the main component of turmeric, might help with reducing belly fat. Learn more: Does turmeric help you lose weight? It may also help improve symptoms of depression and arthritis. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY. Certain herbs and spices are known to have anti-inflammatory properties. Learn about the power of turmeric, ginger, cinnamon, garlic, cayenne, cloves…. Turmeric contains many plant substances, but curcumin is the most powerful. This article looks at the benefits of and key differences between turmeric…. Learn about turmeric tea benefits, who should drink it, and how to make it at home. Golden milk — also known as turmeric milk — is a hot Indian drink made with milk and various spices. Here are 10 science-based benefits of golden milk…. Phosphatidylcholine is known to boost cognition, but its potential benefits don't stop there. Here's what you should know about this herbal remedy. Research suggests rhodiola and ashwagandha work well together, but you may want to take them at different times of day. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 10 Health Benefits of Tumeric and Curcumin. Medically reviewed by Imashi Fernando, MS, RDN, CDCES — By Kris Gunnars, BSc — Updated on November 27, What it is Medicinal properties Anti-inflammatory Antioxidants Brain health Heart disease Cancer Alzheimer's disease Arthritis Depression Aging FAQs Bottom line Many high-quality studies show that turmeric has major benefits for your body and brain. What are turmeric and curcumin? Turmeric contains bioactive compounds with medicinal properties. Curcumin is a natural anti-inflammatory compound. Turmeric can increase the antioxidant capacity of the body. Curcumin can boost brain-derived neurotrophic factor. Curcumin may lower your risk of heart disease. Turmeric may help prevent cancer. Arthritis patients respond well to curcumin supplements. Curcumin has benefits against depression. Curcumin may help delay aging and fight age-related chronic diseases. Frequently asked questions. The bottom line. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Nov 27, Written By Kris Gunnars. Nov 20, Medically Reviewed By Imashi Fernando, MS, RDN, CDCES. Share this article. Read this next. Turmeric and Other Anti-Inflammatory Spices. Medically reviewed by George Krucik, MD, MBA. Turmeric vs Curcumin: Which Should You Take? By Sharon O'Brien MS, PGDip. What Is Turmeric Tea? By Cecilia Snyder, MS, RD. By Alina Petre, MS, RD NL. What Is Phosphatidylcholine and How Is It Used? Medically reviewed by Debra Rose Wilson, Ph. Do Rhodiola Rosea and Ashwagandha Work Well Together? Medically reviewed by Kerry Boyle D. |
| Main Content | Curcuminoid-containing supplements taken on an empty stomach may cause gastritis and peptic ulcer disease In the United States, turmeric is generally recognized as safe GRAS by the FDA as a food additive An increase in gallbladder contractions was observed in 12 healthy people supplemented with single doses of 20 to 40 mg of curcumin , Yet, serious adverse effects have not been reported in humans taking high doses of curcumin. A dose escalation trial in 24 adults found that single oral dosages up to 12 g were safe, and adverse effects, including diarrhea, headache, rash, yellow stool, were not related to dose 7. Another clinical trial in the UK found that curcumin supplementation ranging from 0. Increases in serum alkaline phosphatase and lactate dehydrogenase were also observed in several participants, but it was not clear whether these increases were related to curcumin supplementation or cancer progression 3. Although there is no evidence that dietary consumption of turmeric as a spice adversely affects pregnancy or lactation, the safety of curcumin supplements in pregnancy and lactation has not been established. Curcumin has been found to inhibit platelet aggregation in vitro , , suggesting a potential for curcumin supplementation to increase the risk of bleeding in people taking anticoagulant or antiplatelet medications, such as aspirin, clopidogrel Plavix , dalteparin Fragmin , enoxaparin Lovenox , heparin, ticlopidine Ticlid , and warfarin Coumadin. In cultured breast cancer cells, curcumin inhibited apoptosis induced by the chemotherapeutic agents, camptothecin, mechlorethamine, and doxorubicin at concentrations of 1 to 10 μM In an animal model of breast cancer, dietary curcumin inhibited cyclophosphamide-induced tumor regression. Yet, it is not known whether oral curcumin administration will result in breast tissue concentrations that are high enough to inhibit cancer chemotherapeutic agents in humans Curcuminoids may interfere with the activity of efflux drug transporters of the ATP -binding cassette ABC family, including P-glycoprotein, multidrug resistance protein MRP , and breast cancer-resistant protein BCRP , which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability , Curcumin was also found to affect the activity of phase I biotransformation enzymes like cytochrome P CYP 3A4 CYP3A4 , which catalyzes the metabolism of about one-half of all marketed drugs in the US In healthy Japanese volunteers, curcumin 2 g was found to increase plasma sulfasalazine concentration following the administration of a therapeutic dose 2 g of the anti-rheumatic drug sulfasalazine Salazopyrin, Azulfidine Some curcumin supplements also contain piperine to increase the bioavailability of curcumin. Piperine may also interfere with efflux drug transporters and phase I cytochrome P enzymes and increase the bioavailability and slow the elimination of a number of drugs, including phenytoin Dilantin , propranolol Inderal , theophylline, and carbamazepine Tegretol Originally written in by: Jane Higdon, Ph. Linus Pauling Institute Oregon State University. Updated in January by: Victoria J. Drake, Ph. Updated in February by: Barbara Delage, Ph. Reviewed in March by: Lynne Howells, Ph. Research Fellow Experimental Cancer Medicine Centre Lab Quality Manager University of Leicester. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Bandyopadhyay D. Farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer. Front Chem. Sharma RA, Gescher AJ, Steward WP. Curcumin: The story so far. Eur J Cancer. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci. Baum L, Lam CW, Cheung SK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol. Lao CD, Ruffin MTt, Normolle D, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. Sharma RA, Euden SA, Platton SL, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. Garcea G, Berry DP, Jones DJ, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev. Garcea G, Jones DJ, Singh R, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer. Aggarwal ML, Chacko KM, Kuruvilla BT. Systematic and comprehensive investigation of the toxicity of curcuminoidessential oil complex: A bioavailable turmeric formulation. Mol Med Rep. Jager R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. Kanai M, Imaizumi A, Otsuka Y, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. Mendonca LM, Machado Cda S, Teixeira CC, Freitas LA, Bianchi ML, Antunes LM. Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects. Genet Mol Biol. Shakeri A, Sahebkar A. Optimized curcumin formulations for the treatment of Alzheimer's disease: A patent evaluation. J Neurosci Res. Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. Sreejayan, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids. Dickinson DA, Levonen AL, Moellering DR, et al. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radic Biol Med. Dickinson DA, Iles KE, Zhang H, Blank V, Forman HJ. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J. Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G. Mol Neurobiol. Zhang X, Liang D, Guo L, et al. Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase Suzuki M, Betsuyaku T, Ito Y, et al. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol. Yao QY, Xu BL, Wang JY, Liu HC, Zhang SC, Tu CT. Inhibition by curcumin of multiple sites of the transforming growth factor-β1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. Xiong ZE, Dong WG, Wang BY, Tong QY, Li ZY. Pharmacogn Mag. Xie Y, Zhao QY, Li HY, Zhou X, Liu Y, Zhang H. Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Pharmacol Biochem Behav. Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. Li CP, Li JH, He SY, Chen O, Shi L. Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis. Genet Mol Res. Yang JY, Zhong X, Yum HW, et al. Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice. J Cancer Prev. Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol. Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. Zhu HT, Bian C, Yuan JC, et al. J Neuroinflammation. Baird WM, Hooven LA, Mahadevan B. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen. Sehgal A, Kumar M, Jain M, Dhawan DK. Modulatory effects of curcumin in conjunction with piperine on benzo a pyrene-mediated DNA adducts and biotransformation enzymes. Nutr Cancer. Thapliyal R, Maru GB. Inhibition of cytochrome P isozymes by curcumins in vitro and in vivo. Volak LP, Ghirmai S, Cashman JR, Court MH. Curcuminoids inhibit multiple human cytochromes P, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. Das L, Vinayak M. Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer. PLoS One. Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol. Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci. Duvoix A, Blasius R, Delhalle S, et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. Surh YJ, Chun KS. Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med Chem. Kuttan G, Kumar KB, Guruvayoorappan C, Kuttan R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Chen B, Zhang Y, Wang Y, Rao J, Jiang X, Xu Z. Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression. J Steroid Biochem Mol Biol. Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. Han X, Xu B, Beevers CS, et al. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Huang T, Chen Z, Fang L. Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncol Rep. Prvulovic D, Hampel H. Amyloid beta Aβ and phospho-tau p-τ as diagnostic biomarkers in Alzheimer's disease. Clin Chem Lab Med. Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid β-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. When all else fails, joint replacement surgery can be highly effective. In fact, about a million joint replacements mostly knees and hips are performed each year in the US. My patients often ask about diet, including anti-inflammatory foods, antioxidants, low-gluten diets, and many others. When there is evidence, it usually demonstrates no consistent or clear benefit. A study published in BMC suggests that curcumin, a naturally occurring substance found in a common spice, might help ease osteoarthritis pain. In the study, researchers enrolled people with symptoms of knee osteoarthritis. Ask your health care provider about taking turmeric if you have gallbladder disease, as it may worsen the condition. You also should talk to your health care provider about turmeric if you take an anti-clotting medication or chemotherapy, as the supplement may interact with your medication. adapted from Mayo Clinic Health Letter — Katherine Zeratsky, R. You may be familiar with high-density, or good cholesterol; low-density lipoproteins LDL , or bad cholesterol; and their connections to heart health. But what about triglycerides? Often thatRead more. Lisa Brown, 53, of Jacksonville, suffered from severe pelvis and back pain for years. She later learned that her bladder wasn't working due to follicularRead more. They have a new baby girl, and Dad got the lifesaving heartRead more. By Liza Torborg. |
Curcumin and Inflammation -
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. Mendonca LM, Machado Cda S, Teixeira CC, Freitas LA, Bianchi ML, Antunes LM.
Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects. Genet Mol Biol. Shakeri A, Sahebkar A. Optimized curcumin formulations for the treatment of Alzheimer's disease: A patent evaluation.
J Neurosci Res. Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice.
Cancer Res Treat. Sreejayan, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids.
Dickinson DA, Levonen AL, Moellering DR, et al. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radic Biol Med. Dickinson DA, Iles KE, Zhang H, Blank V, Forman HJ. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.
FASEB J. Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G. Mol Neurobiol. Zhang X, Liang D, Guo L, et al. Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase Suzuki M, Betsuyaku T, Ito Y, et al.
Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol. Yao QY, Xu BL, Wang JY, Liu HC, Zhang SC, Tu CT.
Inhibition by curcumin of multiple sites of the transforming growth factor-β1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. Xiong ZE, Dong WG, Wang BY, Tong QY, Li ZY.
Pharmacogn Mag. Xie Y, Zhao QY, Li HY, Zhou X, Liu Y, Zhang H. Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.
Pharmacol Biochem Behav. Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update.
Food Chem Toxicol. Li CP, Li JH, He SY, Chen O, Shi L. Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis. Genet Mol Res. Yang JY, Zhong X, Yum HW, et al. Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice.
J Cancer Prev. Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol. Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A.
Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.
Biochem Pharmacol. Zhu HT, Bian C, Yuan JC, et al. J Neuroinflammation. Baird WM, Hooven LA, Mahadevan B. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen. Sehgal A, Kumar M, Jain M, Dhawan DK. Modulatory effects of curcumin in conjunction with piperine on benzo a pyrene-mediated DNA adducts and biotransformation enzymes.
Nutr Cancer. Thapliyal R, Maru GB. Inhibition of cytochrome P isozymes by curcumins in vitro and in vivo. Volak LP, Ghirmai S, Cashman JR, Court MH. Curcuminoids inhibit multiple human cytochromes P, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.
Drug Metab Dispos. Das L, Vinayak M. Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer.
PLoS One. Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol.
Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci. Duvoix A, Blasius R, Delhalle S, et al. Chemopreventive and therapeutic effects of curcumin.
Cancer Lett. Surh YJ, Chun KS. Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy.
Anticancer Agents Med Chem. Kuttan G, Kumar KB, Guruvayoorappan C, Kuttan R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Kunnumakkara AB, Anand P, Aggarwal BB.
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Chen B, Zhang Y, Wang Y, Rao J, Jiang X, Xu Z. Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.
J Steroid Biochem Mol Biol. Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. Han X, Xu B, Beevers CS, et al. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.
Huang T, Chen Z, Fang L. Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncol Rep. Prvulovic D, Hampel H. Amyloid beta Aβ and phospho-tau p-τ as diagnostic biomarkers in Alzheimer's disease.
Clin Chem Lab Med. Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid β-aggregation inhibitors based on curcumin: influence of linker length and flexibility.
Chem Biol Drug Des. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. Lin R, Chen X, Li W, Han Y, Liu P, Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
Neurosci Lett. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein.
Shi X, Zheng Z, Li J, et al. Goozee KG, Shah TM, Sohrabi HR, et al. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease.
Br J Nutr. Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP. Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin.
Li N, Chen X, Liao J, et al. Inhibition of 7,dimethylbenz[a]anthracene DMBA -induced oral carcinogenesis in hamsters by tea and curcumin. Ikezaki S, Nishikawa A, Furukawa F, et al. Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats.
Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. Chuang SE, Kuo ML, Hsu CH, et al.
Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Pereira MA, Grubbs CJ, Barnes LH, et al. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,dimethylbenz[a]anthracene-induced mammary cancer in rats.
Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Kawamori T, Lubet R, Steele VE, et al.
Mahmoud NN, Carothers AM, Grunberger D, et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Perkins S, Verschoyle RD, Hill K, et al. Carroll RE, Benya RV, Turgeon DK, et al.
Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res Phila. National Institutes of Health. Clinical Trials. gov [Website]. Rivera-Mancia S, Lozada-Garcia MC, Pedraza-Chaverri J.
Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications. Eur J Pharmacol. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes.
Diabetes Care. Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N. Effect of NCB, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study.
Drugs R D. Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.
J Nutr Biochem. Khajehdehi P, Pakfetrat M, Javidnia K, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study.
Scand J Urol Nephrol. Schaffer M, Schaffer PM, Zidan J, Bar Sela G. Curcuma as a functional food in the control of cancer and inflammation.
Curr Opin Clin Nutr Metab Care. An Introduction to Clinical Trials. Mall M, Kunzelmann K. Correction of the CF defect by curcumin: hypes and disappointments. Irving GR, Howells LM, Sale S, et al.
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration — a clinical pilot study including assessment of patient acceptability.
Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Kanai M, Yoshimura K, Asada M, et al. Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al.
Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. Ghalaut VS, Sangwan L, Dahiya K, Ghalaut PS, Dhankhar R, Saharan R. Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia.
J Oncol Pharm Pract. Mahammedi H, Planchat E, Pouget M, et al. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study.
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Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. Lang A, Salomon N, Wu JC, et al. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial.
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The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Turmeric is the spice that gives curry its yellow color. It has been used in India for thousands of years as both a spice and medicinal herb. Research has shown that turmeric contains compounds with medicinal properties.
These compounds are called curcuminoids. The most important one is curcumin , which is the main active ingredient in turmeric. It has powerful anti-inflammatory effects and is a very strong antioxidant. Most studies on this herb use turmeric extracts that contain mostly curcumin itself, with dosages usually exceeding 1 gram g per day, which means it would be hard to reach these levels just by using turmeric as a spice.
In addition, curcumin is poorly absorbed into your bloodstream. In order to experience the full effects of curcumin, its bioavailability the rate at which your body absorbs a substance needs to improve.
It helps to consume it with black pepper , which contains piperine. In fact, the best curcumin supplements contain piperine, and this makes them substantially more effective.
Curcumin is also fat soluble, which means it breaks down and dissolves in fat or oil. Curcumin is a bioactive substance that can help fight inflammation , though very high doses are required to produce medicinal results. Still, it means it has the potential to fight the inflammation that plays a role in many health conditions and diseases.
It involves free radicals, highly reactive molecules with unpaired electrons. Free radicals tend to react with important organic substances, such as fatty acids, proteins , or DNA. Curcumin is a potent antioxidant that can neutralize free radicals due to its chemical structure. In addition, animal and cellular studies suggest that curcumin may block the action of free radicals and may stimulate the action of other antioxidants.
Further clinical studies are needed in humans to confirm these benefits. Even in adulthood, brain neurons are capable of forming new connections, and in certain areas of the brain, they can multiply and increase in number.
One of the main drivers of this process is brain-derived neurotrophic factor BDNF , which plays a role in memory and learning, and it can be found in areas of the brain responsible for eating, drinking, and body weight.
Both animal and human studies have found that curcumin may increase brain levels of BDNF. By doing this, it may be effective in delaying or even reversing many brain diseases and age-related decreases in brain function. It may also help improve memory and attention , which seems logical given its effects on BDNF levels.
However, more studies are needed to confirm this. Heart disease is the number one cause of death in the world. Research suggests that curcumin may help protect against many steps in the heart disease process.
Specifically, it helps improve the function of the endothelium or the lining of your blood vessels. Endothelial dysfunction is a major driver of heart disease.
This is when your endothelium is unable to regulate blood pressure, blood clotting, and various other factors. Several other studies also suggest that curcumin can lead to improvements in heart health.
In addition, curcumin can help reduce inflammation and oxidation as discussed above , which can play a role in heart disease.
Many different forms of cancer appear to be affected by curcumin supplements. In fact, curcumin has been studied as a beneficial herb in cancer treatment and has been found to affect cancer growth and development. Studies have shown that it can:.
There is also evidence that curcumin may prevent cancer from occurring in the first place, especially cancers of the digestive system like colorectal cancer. In addition, research suggests that curcumin can help clear the buildup of protein tangles called amyloid plaques that are caused by the disease.
There are several different types of arthritis , most of which involve inflammation in the joints. In a study on people with osteoarthritis, curcumin appeared to be more effective in relieving pain than a placebo, and research has also found its effect to be similar to that of non-steroidal anti-inflammatory drugs NSAIDs.
In another study on rheumatoid arthritis, curcumin appeared to have helped reduce disease-related inflammation. That said, more study is needed to understand if curcumin can actually replace such drugs as a treatment for arthritis inflammation pain.
Curcumin has shown some promise in treating mood disorders. Its positive effects on the brain include boosting the brain neurotransmitters serotonin and dopamine, reducing inflammation, and encouraging brain plasticity. This suggests the herb may be an effective antidepressant.
Depression is also linked to reduced levels of BDNF and a shrinking hippocampus, a brain area with a role in learning and memory. Curcumin can help boost BDNF levels , potentially reversing some of these changes. A animal study also found that curcumin may help reduce anxiety, though studies on humans are needed to verify this.
Given that oxidation and inflammation are believed to play a role in aging, curcumin may have effects that go way beyond just preventing disease. If you stick to 12 g or less , you are not likely to experience side effects such as diarrhea, constipation, or vomiting.
Learn more about turmeric dosage. People who are pregnant or nursing, people who have gallbladder or kidney problems, those with bleeding disorders, diabetes, or iron deficiency should limit turmeric.
If you have any of these conditions, ask your doctor before taking turmeric. There is research suggesting that curcumin, the main component of turmeric, might help with reducing belly fat.
Learn more: Does turmeric help you lose weight?
Have you Cuecumin the Endurance training for volleyball players around Curcumin and Inflammation A relatively Curcumin and Inflammation Inlammation trend, this Curcumin and Inflammation is praised for its ability Curcumin and Inflammation reduce inflammation. But, when Inflammaton comes to using Chrcumin as an anti-inflammatory, UnityPoint Health Dietitian Krista Kohls, CCurcumin, CD, explains what you should keep in mind before you hop on the turmeric train. Turmeric is a spice that comes from the root of the turmeric plant. Turmeric has also been applied to the skin for pain or swelling, and the essential oil can be used in perfume. The supplement form of turmeric usually contains more of the spice than what is used in cooking, and Kohls says high levels of turmeric are what reportedly help inflammation, as well as other conditions:. So, is turmeric an effective anti-inflammatory? Curcumin and Inflammation -
Learn more about how curcumin, a chemical in the spice turmeric, may help reduce arthritis symptoms. Get involved with the arthritis community. By Linda Rath Updated March 1, Turmeric has moved to the top of the healthy food chain. The 4,year-old staple of Southeast Asian cooking is showing up everywhere, including ballpark snacks and Starbucks lattes.
But does adding turmeric to your latte or plate of chicken masala do these things? Not likely, says Randy Horowitz, MD, medical director of the University of Arizona Center for Integrative Medicine in Tucson.
Ground turmeric has other strikes against it. Some additives, like vibrantly yellow lead chromate, are toxic. In the last few years, 13 brands of turmeric have been recalled for lead contamination.
How Curcumin Works Curcumin seems to target specific molecules or pathways that control the cell cycle. It also blocks inflammatory cytokines and enzymes, including cyclooxygenase-2 COX-2 , the target of the pain reliever celecoxib Celebrex.
For example, a review of 15 randomized controlled trials found curcumin relieved OA pain and stiffness as well or better than nonsteroidal anti-inflammatories NSAIDs like ibuprofen and celecoxib — minus potentially serious side effects.
Doses ranged from 40 mg of a highly bioavailable form of curcumin to 1, mg. assessed a rat model of MI in which they ligated the left anterior descending artery. reported that curcumin inhibited NF-kappaB activation in the nucleus of cardiomyocytes, thus reducing TNF-alpha, IL-6 and IL-8 levels in the blood, and that it inhibited monocyte apoptosis.
Completed Randomised Trials into Curcurmin. Results of Studies of Curcumin. Early growth response 1 plays a key role in the pathophysiology of acute and chronic cardiovascular disease and is associated with induction of TNF-alpha and IL-6 expression.
Wang et al. studied a rat model of myocardial ischaemia—reperfusion injury and found that previous administration of curcumin inhibited early growth response 1 expression and reduced the infarct size. Myocarditis is often induced by a viral infection but has non-infectious causes, including autoimmune disorders.
Chronic inflammation and subsequent myocyte death are associated with heart failure. Patients with heart failure have an abnormal immune response that disrupts wound healing and prolongs inflammation, consequently worsening heart failure.
The impact of curcumin in myocarditis has been studied using a number of rodent models. In coxsackievirus B3-induced myocarditis, curcumin inhibited the phosphatidylinositol-3 kinase—Akt—NF-kappaB signalling pathway and inhibited the expression of inflammatory cytokines, such as TNF-alpha, IL-6 and IL-1beta, both systemically and in the myocardium; thus, reducing the inflammatory response.
evaluated a mouse model of myocarditis caused by the protozoan parasite Trypanosoma cruzi and reported that curcumin inhibited the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the myocardium as well as inhibiting inflammation in the myocardium and increased the survival rate of mice.
Curcumin inhibited the expression of TNF-alpha and IL-6 and increased the expression of IL-4 and IL in autoimmune acute myocarditis induced by cardiac myosin. Morimoto et al. studied two rat models of heart failure caused by hypertension and MI and showed that curcumin inhibits p histone acetyltransferase activity, thus inhibiting the development of left ventricular hypertrophy and left ventricular systolic dysfunction.
COPD is a family of diseases mainly characterised by airflow obstruction due to airway inflammation and remodelling. Several clinical studies have demonstrated the relationship between COPD and an increase in inflammatory markers, such as TNF-alpha, IL-6 and CRP.
The most common comorbidity in patients with mild-to-moderate COPD is cardiovascular disease. One study suggested that chronic inflammation due to COPD exacerbates atherosclerosis, both directly and indirectly, and promotes thrombosis by weakening plaque.
Several studies have demonstrated the possible benefits of curcumin in COPD. Moghaddam et al. used a mouse model of K-ras-induced lung cancer in which Haemophilus influenzae induced COPD-like airway inflammation and showed that curcumin inhibited neutrophil migration to the lungs. studied a mouse model of COPD induced by lipopolysaccharide and cigarette smoke, reporting that curcumin inhibited the degradation of IkappaB-alpha protein and the expression of cyclooxygenase-2, thus reducing airway inflammation and remodelling.
conducted a clinical trial including patients with mild COPD in which the oxidised LDL — alphaantitrypsin LDL — was significantly decreased in those taking highly absorbable curcumin compared with those taking a placebo. Adipose tissue is a multifunctional endocrine organ that releases various inflammatory and anti-inflammatory cytokines and physiologically active peptides.
In obese patients, the secretion of inflammatory adipocytokines, such as TNF-alpha and IL-6, is increased and the secretion of anti-inflammatory adipocytokines is inhibited in enlarged mast cells in the visceral adipose tissue.
Several rodent studies have assessed the effects of curcumin in models of obesity. In a mouse model of obesity due to a high-fat diet and in a model of genetic obesity, curcumin reduced macrophage invasion of adipose tissue, increased adiponectin production which has anti-inflammatory and anti-atherosclerotic actions and inhibited adipose tissue inflammation.
Pan et al. evaluated a mouse model of obesity due to a high-fat diet and reported that ingestion of curcumin inhibited weight gain, reduced fat accretion due to a high-fat diet and significantly improved the serum lipid profile including serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and free fatty acids.
Further, curcumin broke down lipids and improved glycolipid metabolism. Jazayeri-Tehrani et al. conducted a clinical trial involving 84 overweight or obese patients who were diagnosed with non-alcoholic steatohepatitis.
There was also increased absorption efficiency in patients taking nanocurcumin compared to those taking placebo. Nesfatin, an appetite-regulating protein, is significantly increased in patients taking nanocurcumin.
When patients taking placebo were compared with those taking nanocurcumin, the two groups had a similar percentage decrease in BMI, but those taking nanocurcumin had a significantly greater percentage decrease in abdominal circumference.
In people with type 2 diabetes, trials have shown that curcumin decreased leptin and increased adiponectin in the blood and resulted in improved lipid metabolism. Over the past few years, the role of inflammation has been recognised in the onset and progression of dementia.
Research into the possible impact of curcumin on dementia is currently very limited. However, Liu et al. found that curcumin significantly reduced spatial memory deficit and promoted the function of cholinergic neurons in mice; this improvement was associated with the inhibition of NF-kappaB signalling pathways and enhanced transcription by PPAR-gamma.
reported that highly absorbable curcumin reduced amyloid and tau accumulation in the brains of adults with no cognitive impairment and may consequently improve memory and attention. The anti-inflammatory effect of curcumin forms the basis for its potential clinical applications Figure 2.
A large body of clinical evidence is expected to accumulate in the future. Among trials registered at Clinicaltrials. gov, studies are related to the anti-inflammatory effect of curcumin. Of these, 50 are currently on-going, 70 are complete and 42 have been withdrawn, have unknown status or have been terminated.
Of the 50 completed studies, the 10 randomised double-blind and placebo-controlled comparative studies are listed in Table 1. The results of eight of these studies were significant. Curcumin has beneficial effects on the status of various diseases involving chronic inflammation.
However, the absorption of curcumin is poor, and even if absorbed into the body it is rapidly metabolised and excreted in faeces. These include polymer nanoparticles, chitosan nanoparticles, colloidal nanoparticles, nanoemulsion and ligand-targeted liposomes.
The beneficial effects of these drug delivery systems on curcumin bioavailability have been reported in streptozotocin-induced diabetic rats, a pulmonary fibrosis rat model, a dextran sulphate sodium-induced inflammatory bowel disease mouse model and a lipopolysaccharide-stimulated acute inflammation mouse model.
Moreover, Funamoto et al. reported that curcumin dispersed with colloidal nanoparticles Theracurmin ® suppressed an increase in alpha1-antitrypsin LDL levels in people with mild COPD. The Mechanisms of Curcumin Action on Inflammation.
A number of studies have reported the efficacy of curcurmin and the mechanisms by which its anti-inflammatory activity could treat various lifestyle-related conditions associated with chronic inflammation, including atherosclerosis, heart failure, obesity, diabetes and other related diseases, such as dementia.
Most of these studies have involved animal experiments; however, there are several reports on the benefits of curcumin use in humans. Because curcumin has extremely low bioavailability in humans, an appropriate drug delivery system is necessary for its clinical application.
It is important to study the relationship between the structure and activity of curcumin and to develop novel compounds that are more effective than natural curcumin. Additional clinical trials involving drug delivery systems for curcumin in humans need to be conducted to determine the benefits of curcumin treatment in conditions associated with inflammation.
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Keywords Inflammation , curcumin , lifestyle-related diseases , cardiovascular risk factor , natural product ,. Citation ×. Select format. ris Mendeley, Papers, Zotero. enw EndNote. bibtex BibTex. txt Medlars, RefWorks. Open Access: This work is open access under the CC-BY-NC 4.
Curcumin and Atherosclerosis Risk factors for atherosclerosis, including hypertension, diabetes and smoking, cause a chronic inflammatory response. Curcumin and Chronic Obstructive Pulmonary Disease COPD is a family of diseases mainly characterised by airflow obstruction due to airway inflammation and remodelling.
Drug Delivery Systems Curcumin has beneficial effects on the status of various diseases involving chronic inflammation.
Conclusion A number of studies have reported the efficacy of curcurmin and the mechanisms by which its anti-inflammatory activity could treat various lifestyle-related conditions associated with chronic inflammation, including atherosclerosis, heart failure, obesity, diabetes and other related diseases, such as dementia.
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Masafumi Funamoto. Yoichi Sunagawa. Satoshi Shimizu. Yasufumi Katanasaka. Yusuke Miyazaki. Hiromichi Wada. Koji Hasegawa.
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